Adenosine diphosphate ribose

Multi tool use
Adenosine diphosphate ribose

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Names
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Other names
ADP ribose
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Identifiers
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CAS Number
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20762-30-5 N
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3D model (JSmol)
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ChEMBL
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ChEMBL1161865 N
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ChemSpider
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388340 N
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MeSH
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Adenosine+Diphosphate+Ribose
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InChI
InChI=1S/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(24)9(23)6(31-14)2-30-35(26,27)34-36(28,29)33-15-11(25)8(22)5(1-21)32-15/h3-6,8-11,14-15,21-25H,1-2H2,(H4,16,17,18,26,27,28,29)/p+1/t5-,6+,8-,9+,10+,11-,14+,15+/m0/s1 N
Key: YNCNQNWXUFCWJS-DKMYFHGXSA-O N
InChI=1/C15H23N5O14P2/c16-12-7-13(18-3-17-12)20(4-19-7)14-10(24)9(23)6(31-14)2-30-35(26,27)34-36(28,29)33-15-11(25)8(22)5(1-21)32-15/h3-6,8-11,14-15,21-25H,1-2H2,(H4,16,17,18,26,27,28,29)/p+1/t5-,6+,8-,9+,10+,11-,14+,15+/m0/s1
Key: YNCNQNWXUFCWJS-LKOYDKQFBH
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SMILES
O=P(O[C@H]1O[C@H]([C@H](O)[C@@H]1O)CO)(O)OP(=O)(OC[C@H]4O[C@@H](n3c2ncnc(N)c2nc3)[C@H](O)[C@@H]4O)O
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Properties
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Chemical formula
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C15H23N5O14P2
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Molar mass
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559.316 g/mol
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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N verify (what is Y N ?)
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Infobox references
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Adenosine diphosphate ribose is an ester molecule formed into chains by the enzyme poly ADP ribose polymerase. It binds to and activates the TRPM2 ion channel.[1]
See also
- Adenosine diphosphate
- Ribose
References
^ Fonfria E, Marshall IC, Benham CD, et al. (September 2004). "TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase". Br. J. Pharmacol. 143 (1): 186–92. doi:10.1038/sj.bjp.0705914. PMC 1575275. PMID 15302683..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
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TRPA |
Activators |
- 4-Hydroxynonenal
- 4-Oxo-2-nonenal
- 4,5-EET
- 12S-HpETE
- 15-Deoxy-Δ12,14-prostaglandin J2
α-Sanshool (ginger, Sichuan and melegueta peppers)
- Acrolein
Allicin (garlic)
Allyl isothiocyanate (mustard, radish, horseradish, wasabi)
- AM404
- Bradykinin
Cannabichromene (cannabis)
Cannabidiol (cannabis)
Cannabigerol (cannabis)
Cinnamaldehyde (cinnamon)
- CR gas (dibenzoxazepine; DBO)
- CS gas (2-chlorobenzal malononitrile)
Curcumin (turmeric)
Dehydroligustilide (celery)
- Diallyl disulfide
Dicentrine (Lindera spp.)
- Farnesyl thiosalicylic acid
- Formalin
Gingerols (ginger)
- Hepoxilin A3
- Hepoxilin B3
- Hydrogen peroxide
- Icilin
- Isothiocyanate
Ligustilide (celery, Angelica acutiloba)
Linalool (Sichuan pepper, thyme)
- Methylglyoxal
Methyl salicylate (wintergreen)
- N-Methylmaleimide
Nicotine (tobacco)
Oleocanthal (olive oil)
Paclitaxel (Pacific yew)
- Paracetamol (acetaminophen)
- PF-4840154
- Phenacyl chloride
Polygodial (Dorrigo pepper)
Shogaols (ginger, Sichuan and melegueta peppers)
- Tear gases
Tetrahydrocannabinol (cannabis)
Thiopropanal S-oxide (onion)
Umbellulone (Umbellularia californica)
- WIN 55,212-2
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Blockers |
Dehydroligustilide (celery)
Nicotine (tobacco)
- Ruthenium red
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TRPC |
Activators |
Adhyperforin (St John's wort)
- Diacyl glycerol
- GSK1702934A
Hyperforin (St John's wort)
- Substance P
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Blockers |
- DCDPC
- DHEA-S
- Flufenamic acid
- GSK417651A
- GSK2293017A
- Meclofenamic acid
- N-(p-Amylcinnamoyl)anthranilic acid
- Niflumic acid
- Pregnenolone sulfate
- Progesterone
- Pyr3
- Tolfenamic acid
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TRPM |
Activators |
- ADP-ribose
- BCTC
Calcium (intracellular)
- Cold
- Coolact P
- Cooling Agent 10
- CPS-369
Eucalyptol (eucalyptus)
- Frescolat MGA
- Frescolat ML
- Geraniol
- Hydroxycitronellal
- Icilin
- Linalool
Menthol (mint)
- PMD 38
- Pregnenolone sulfate
Rutamarin (Ruta graveolens)
Steviol glycosides (e.g., stevioside) (Stevia rebaudiana)
- Sweet tastants (e.g., glucose, fructose, sucrose; indirectly)
- Thio-BCTC
- WS-3
- WS-12
- WS-23
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Blockers |
- Capsazepine
- Clotrimazole
- DCDPC
- Elismetrep
- Flufenamic acid
- Meclofenamic acid
- Mefenamic acid
- N-(p-Amylcinnamoyl)anthranilic acid
Nicotine (tobacco)
- Niflumic acid
- Ruthenium red
Rutamarin (Ruta graveolens)
- Tolfenamic acid
- TPPO
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TRPML |
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TRPP |
Activators |
Triptolide (Tripterygium wilfordii)
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Blockers |
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TRPV |
Activators |
- 2-APB
- 5',6'-EET
- 9-HODE
- 9-oxoODE
- 12S-HETE
- 12S-HpETE
- 13-HODE
- 13-oxoODE
- 20-HETE
α-Sanshool (ginger, Sichuan and melegueta peppers)
Allicin (garlic)
- AM404
- Anandamide
Bisandrographolide (Andrographis paniculata)
Camphor (camphor laurel, rosemary, camphorweed, African blue basil, camphor basil)
Cannabidiol (cannabis)
Cannabidivarin (cannabis)
Capsaicin (chili pepper)
Carvacrol (oregano, thyme, pepperwort, wild bergamot, others)
- DHEA
- Diacyl glycerol
Dihydrocapsaicin (chili pepper)
- Estradiol
Eugenol (basil, clove)
Evodiamine (Euodia ruticarpa)
Gingerols (ginger)
- GSK1016790A
- Heat
- Hepoxilin A3
- Hepoxilin B3
Homocapsaicin (chili pepper)
Homodihydrocapsaicin (chili pepper)
Incensole (incense)
- Lysophosphatidic acid
- Low pH (acidic conditions)
Menthol (mint)
- N-Arachidonoyl dopamine
- N-Oleoyldopamine
- N-Oleoylethanolamide
Nonivamide (PAVA) (PAVA spray)
Nordihydrocapsaicin (chili pepper)
Paclitaxel (Pacific yew)
- Paracetamol (acetaminophen)
Phorbol esters (e.g., 4α-PDD)
Piperine (black pepper, long pepper)
Polygodial (Dorrigo pepper)
- Probenecid
- Protons
- RhTx
Rutamarin (Ruta graveolens)
Resiniferatoxin (RTX) (Euphorbia resinifera/pooissonii)
Shogaols (ginger, Sichuan and melegueta peppers)
Tetrahydrocannabivarin (cannabis)
Thymol (thyme, oregano)
Tinyatoxin (Euphorbia resinifera/pooissonii)
- Tramadol
Vanillin (vanilla)
- Zucapsaicin
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Blockers |
α-Spinasterol (Vernonia tweediana)
- AMG-517
- Asivatrep
- BCTC
Cannabigerol (cannabis)
Cannabigerolic acid (cannabis)
Cannabigerovarin (cannabis)
Cannabinol (cannabis)
- Capsazepine
- DCDPC
- DHEA
- DHEA-S
- Flufenamic acid
- GRC-6211
- HC-067047
- Lanthanum
- Mavatrep
- Meclofenamic acid
- N-(p-Amylcinnamoyl)anthranilic acid
- NGD-8243
- Niflumic acid
- Pregnenolone sulfate
- RN-1734
- RN-9893
- Ruthenium red
- SB-705498
- Tivanisiran
- Tolfenamic acid
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See also: Receptor/signaling modulators • Ion channel modulators |
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