Embryo






















Embryo

Embryo 7 weeks after conception.jpg
A human embryo, seven weeks old
or nine weeks' gestational age

Identifiers
MeSH D004622
TE E1.0.2.6.4.0.8
FMA 69068

Anatomical terminology
[edit on Wikidata]


An embryo is an early stage of development of a multicellular diploid eukaryotic organism. In general, in organisms that reproduce sexually, an embryo develops from a zygote, the single cell resulting from the fertilization of the female egg cell by the male sperm cell. The zygote possesses half the DNA from each of its two parents. In plants, animals, and some protists, the zygote will begin to divide by mitosis to produce a multicellular organism. The result of this process is an embryo.


In human pregnancy, a developing fetus is considered as an embryo until the ninth week, fertilization age, or eleventh-week gestational age. After this time the embryo is referred to as a fetus.[1]




Contents






  • 1 Etymology


  • 2 Development


    • 2.1 Plant embryos




  • 3 Research and technology


    • 3.1 Fossilized embryos




  • 4 Miscarriage and abortion


  • 5 See also


  • 6 Notes


  • 7 External links





Etymology


First attested in English in the mid-14c., the word embryon derives from Medieval Latin embryo, itself from Greek ἔμβρυον (embruon), lit. "young one",[2] which is the neuter of ἔμβρυος (embruos), lit. "growing in",[3] from ἐν (en), "in"[4] and βρύω (bruō), "swell, be full";[5] the proper Latinized form of the Greek term would be embryum.



Development





File:Embryonic development of a salamander, filmed in the 1920s.ogvPlay media

Embryonic development of salamander, circa the 1920s




Embryos (and one tadpole) of the wrinkled frog (Rana rugosa)


In animals, the development of the zygote into an embryo proceeds through specific recognizable stages of blastula, gastrula, and organogenesis. The blastula stage typically features a fluid-filled cavity, the blastocoel, surrounded by a sphere or sheet of cells, also called blastomeres. In a placental mammal, an ovum is fertilized in a fallopian tube through which it travels into the uterus. An embryo is called a fetus at a more advanced stage of development and up until birth or hatching. In humans, this is from the eleventh week of gestation. However, animals which develop in eggs outside the mother's body, are usually referred to as embryos throughout development; e.g. one would refer to a chick embryo, not a "chick fetus", even at later stages.


During gastrulation the cells of the blastula undergo coordinated processes of cell division, invasion, and/or migration to form two (diploblastic) or three (triploblastic) tissue layers. In triploblastic organisms, the three germ layers are called endoderm, ectoderm, and mesoderm. The position and arrangement of the germ layers are highly species-specific, however, depending on the type of embryo produced. In vertebrates, a special population of embryonic cells called the neural crest has been proposed as a "fourth germ layer", and is thought to have been an important novelty in the evolution of head structures.


During organogenesis, molecular and cellular interactions between germ layers, combined with the cells' developmental potential, or competence to respond, prompt the further differentiation of organ-specific cell types.[citation needed] For example, in neurogenesis, a subpopulation of ectoderm cells is set aside to become the brain, spinal cord, and peripheral nerves. Modern developmental biology is extensively probing the molecular basis for every type of organogenesis, including angiogenesis (formation of new blood vessels from pre-existing ones), chondrogenesis (cartilage), myogenesis (muscle), osteogenesis (bone), and many others.



Plant embryos





The inside of a Ginkgo seed, showing the embryo


In botany, a seed plant embryo is part of a seed, consisting of precursor tissues for the leaves, stem (see hypocotyl), and root (see radicle), as well as one or more cotyledons. Once the embryo begins to germinate—grow out from the seed—it is called a seedling (plantlet).


Bryophytes and ferns also produce an embryo, but do not produce seeds. In these plants, the embryo begins its existence attached to the inside of the archegonium on a parental gametophyte from which the egg cell was generated. The inner wall of the archegonium lies in close contact with the "foot" of the developing embryo; this "foot" consists of a bulbous mass of cells at the base of the embryo which may receive nutrition from its parent gametophyte. The structure and development of the rest of the embryo varies by group of plants. Once the embryo has expanded beyond the enclosing archegonium, it is no longer termed an embryo.



Research and technology


Embryos are used in various fields of research and in techniques of assisted reproductive technology. An egg may be fertilized in vitro and the resulting embryo may be frozen for later use.
The potential of embryonic stem cell research, reproductive cloning, and germline engineering are currently being explored. Prenatal diagnosis or preimplantation diagnosis enables testing embryos for diseases or conditions.


Cryoconservation of animal genetic resources is a practice in which animal germplasms, such as embryos are collected and stored at low temperatures with the intent of conserving the genetic material.


The embryos of Arabidopsis thaliana have been used as a model to understand gene activation, patterning, and organogenesis of seed plants.[6]


In regards to research using human embryos, the ethics and legalities of this application continue to be debated.[7][8][9]


Researchers from MERLN Institute and the Hubrecht Institute in the Netherlands managed to grow samples of synthetic rodent embryos, combining certain types of stem cells. This method will help scientists to more deeply study the very first moments of the process of the birth of a new life, which, in turn, can lead to the emergence of new effective methods to combat infertility and other genetic diseases.[10]



Fossilized embryos



Fossilized animal embryos are known from the Precambrian, and are found in great numbers during the Cambrian period. Even fossilized dinosaur embryos have been discovered.[11]



Miscarriage and abortion





A complete spontaneous abortion at about 6 weeks from conception, i.e. 8 weeks from LMP


Some embryos do not survive to the next stage of development. When this happens naturally, it is called spontaneous abortion or miscarriage.[12] There are many reasons why this may occur. The most common natural cause of miscarriage is chromosomal abnormality in animals[13] or genetic load in plants.[14]


In species which produce multiple embryos at the same time, miscarriage or abortion of some embryos can provide the remaining embryos with a greater share of maternal resources. This can also disturb the pregnancy, causing harm to the second embryo. Genetic strains which miscarry their embryos are the source of commercial seedless fruits.


Abortion is the process of artificially (non-naturally) removing the embryo through deliberate pharmaceutical or surgical methods.



See also



  • In vitro fertilisation

  • Plant embryogenesis

  • Pregnancy

  • Prenatal development

  • Proembryo



Notes





  1. ^ "embryo". Mayo. Archived from the original on 20 February 2016. Retrieved 21 February 2016..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ ἔμβρυον Archived 2013-05-31 at the Wayback Machine., Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus


  3. ^ ἔμβρυος Archived 2013-05-31 at the Wayback Machine., Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus


  4. ^ ἐν Archived 2013-05-31 at the Wayback Machine., Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus


  5. ^ βρύω Archived 2013-05-31 at the Wayback Machine., Henry George Liddell, Robert Scott, A Greek-English Lexicon, on Perseus


  6. ^ Boscá, S; Knauer, S; Laux, T (2011). "Embryonic development in Arabidopsis thaliana: from the zygote division to the shoot meristem". Frontiers in Plant Science. 2: 93. doi:10.3389/fpls.2011.00093. PMC 3355580. PMID 22639618.


  7. ^ Freedman, Jeri. "America Debates Stem Cell Research." New York, NY: The Rosen Publishing Group, 2008.


  8. ^ Sandel, Michael J. "The Case Against Perfection." Michael J. Sandel, 2007.


  9. ^ Zavos, Panayiotis. "Reproductive Cloning is Moral." Ed. James Woodward. The Ethics of Human Cloning: At Issue. Farmington Hills, MI: Greenhaven, 2005. 14–24.


  10. ^ "Scientists grow synthetic mouse embryos from stem cells" Archived 2018-05-08 at the Wayback Machine. New Atlas, May 4, 2018


  11. ^ Morelle, Rebecca. "Dinosaur embryo fossils reveal life inside the egg". BBC News. Archived from the original on 24 September 2015. Retrieved 8 August 2015.


  12. ^ miscarriage "Archived copy". Archived from the original on 2016-05-12. Retrieved 2016-05-15.CS1 maint: Archived copy as title (link)


  13. ^ Conrad Stöppler, Melissa. Shiel, Jr., William C., ed. "Miscarriage (Spontaneous Abortion)". MedicineNet.com. Archived from the original on 2004-08-29. Retrieved 2009-04-07.


  14. ^ Kärkkäinen, Katri; Savolainen, Outi; Koski, Veikko (1999). "Why do plants abort so many developing seeds: bad offspring or bad maternal genotypes?". Evolutionary Ecology. 13 (3): 305–317. doi:10.1023/A:1006746900736.




External links











  • UNSW Embryology - Educational website

  • A Comparative Embryology Gallery

  • 4-H Embryology, University of Nebraska-Lincoln Extension in Lancaster County


  • Video with embryo of a small-spotted catshark inside the egg on YouTube






Preceded by
Zygote

Animal development
Embryo
Succeeded by
Fetus, Hatchling, Larva










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