SLC20A2































































SLC20A2
Identifiers
Aliases
SLC20A2, GLVR-2, GLVR2, IBGC1, IBGC3, MLVAR, PIT-2, PIT2, RAM1, Ram-1, solute carrier family 20 member 2
External IDs MGI: 97851 HomoloGene: 68531 GeneCards: SLC20A2


















Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]

Chromosome 8 (human)
Genomic location for SLC20A2

Genomic location for SLC20A2

Band 8p11.21 Start 42,416,475 bp[1]
End 42,541,926 bp[1]























RNA expression pattern
PBB GE SLC20A2 202744 at fs.png
More reference expression data















Orthologs
Species Human Mouse
Entrez


6575


20516
Ensembl


ENSG00000168575


ENSMUSG00000037656
UniProt


Q08357


Q80UP8
RefSeq (mRNA)


NM_001257180
NM_001257181
NM_006749


NM_011394
RefSeq (protein)


NP_001244109
NP_001244110
NP_006740


NP_035524
Location (UCSC) Chr 8: 42.42 – 42.54 Mb Chr 8: 22.48 – 22.57 Mb

PubMed search		 [3] [4]
Wikidata



View/Edit Human View/Edit Mouse

Sodium-dependent phosphate transporter 2 is a protein that in humans is encoded by the SLC20A2 gene.[5][6][7]




Contents






  • 1 Genomics


  • 2 Function


  • 3 Clinical significance


  • 4 See also


  • 5 References


  • 6 Further reading





Genomics


This gene is found on the short arm of chromosome 8 (8p12-p11) on the minus (Crick) strand. It is 123,077 bases in length. The encoded protein has 652 amino acids and the predicted molecular weight of the protein is 70.392 kiloDaltons.



Function


The protein acts as a homodimer and is involved in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis.



Clinical significance


Mutations in the SLC20a2 gene are associated with idiopathic basal ganglia calcification (Fahr's syndrome). This association suggests that familial idiopathic basal ganglia calcification is caused by changes in phosphate homeostasis, since this gene encodes for PIT-2, an inorganic phosphate transporter.[8]



See also


  • Solute carrier family


References





  1. ^ abc GRCh38: Ensembl release 89: ENSG00000168575 - Ensembl, May 2017


  2. ^ abc GRCm38: Ensembl release 89: ENSMUSG00000037656 - Ensembl, May 2017


  3. ^ "Human PubMed Reference:"..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output .citation q{quotes:"""""""'""'"}.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/4/4c/Wikisource-logo.svg/12px-Wikisource-logo.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-maint{display:none;color:#33aa33;margin-left:0.3em}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  4. ^ "Mouse PubMed Reference:".


  5. ^ Kozak SL, Siess DC, Kavanaugh MP, Miller AD, Kabat D (Jun 1995). "The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species". J Virol. 69 (6): 3433–40. PMC 189055. PMID 7745689.


  6. ^ Bottger P, Hede SE, Grunnet M, Hoyer B, Klaerke DA, Pedersen L (Nov 2006). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2". Am J Physiol Cell Physiol. 291 (6): C1377–87. doi:10.1152/ajpcell.00015.2006. PMID 16790504.


  7. ^ "Entrez Gene: SLC20A2 solute carrier family 20 (phosphate transporter), member 2".


  8. ^ Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, de Oliveira JR, Sobrido MJ, Quintáns B, Baquero M, Cui X, Zhang XY, Wang L, Xu H, Wang J, Yao J, Dai X, Liu J, Zhang L, Ma H, Gao Y, Ma X, Feng S, Liu M, Wang QK, Forster IC, Zhang X, Liu JY (February 2012). "Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis". Nat Genet. 44 (3): 254–6. doi:10.1038/ng.1077. PMID 22327515.




Further reading


.mw-parser-output .refbegin{font-size:90%;margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{list-style-type:none;margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li,.mw-parser-output .refbegin-hanging-indents>dl>dd{margin-left:0;padding-left:3.2em;text-indent:-3.2em;list-style:none}.mw-parser-output .refbegin-100{font-size:100%}



  • Garcia JV, Jones C, Miller AD (1991). "Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8". J. Virol. 65 (11): 6316–9. PMC 250343. PMID 1656098.


  • van Zeijl M, Johann SV, Closs E, et al. (1994). "A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1168–72. doi:10.1073/pnas.91.3.1168. PMC 521475. PMID 8302848.


  • Salaün C, Gyan E, Rodrigues P, Heard JM (2002). "Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration". J. Virol. 76 (9): 4304–11. doi:10.1128/JVI.76.9.4304-4311.2002. PMC 155110. PMID 11932396.


  • Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function". J. Biol. Chem. 277 (45): 42741–7. doi:10.1074/jbc.M207096200. PMID 12205090.


  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.


  • Bøttger P, Pedersen L (2004). "The central half of Pit2 is not required for its function as a retroviral receptor". J. Virol. 78 (17): 9564–7. doi:10.1128/JVI.78.17.9564-9567.2004. PMC 506934. PMID 15308749.


  • Bøttger P, Pedersen L (2005). "Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2". FEBS J. 272 (12): 3060–74. doi:10.1111/j.1742-4658.2005.04720.x. PMID 15955065.


  • Ravera S, Virkki LV, Murer H, Forster IC (2007). "Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements". Am. J. Physiol., Cell Physiol. 293 (2): C606–20. doi:10.1152/ajpcell.00064.2007. PMID 17494632.












-

Popular posts from this blog

澳門輕軌系統

Image
本文或本章節是關於未來的公共运输建設或計划。 未有可靠来源的臆測內容可能會被移除，現時內容可能與竣工情況有所出入。 本文或本章節是關於澳門未來的建設或計畫 。 它可能包含推测的性质的信息，可能與竣工情況有所出入。 body.skin-minerva .mw-parser-output table.infobox caption{text-align:center} 澳門輕軌系統 葡萄牙語： Sistema de Metro Ligeiro de Macau 英语： Macau Light Rapid Transit System (Macau LRT System) 概覽 營運地區   澳門 服務類型 輕軌運輸 车站总数 氹仔線：11個 澳門半島線：10個 起訖站点 關閘 正線总数 3條 主要路線 海洋 - 氹仔碼頭 路線等級 輕軌 主要車站 蓮花口岸、 機場、氹仔碼頭 技術數據 路線長度 氹仔線：9.3公里 軌道標準 膠輪路軌系統 动力方式 第三軌供電 750V 車輛基地 計劃興建總數11個： 澳門半島6個，氹仔5個 运营信息 營運時期 氹仔線：預計於2019年 运营单位 港鐵（澳門）（2019年－2023年） 澳門輕軌股份有限公司（2023年後） 網站 http://www.git.gov.mo 路線圖 各期工程完成後的路線走向（模擬）圖 澳門輕軌系統（未來） 圖例 關閘 馬場北 馬場東 青洲 A區車廠 筷子基 新城A區01 紅街市
Read more

水泉澳邨

Image
水泉澳邨 //upload.wikimedia.org/wikipedia/commons/6/66/Shui_Chuen_O_Estate_Overview_2016.jpg 水泉澳邨航拍圖 房屋機構 香港房屋委員會 所屬地區 沙田區 屋邨類別 租住屋邨 入伙年份 2015年至2017年 樓宇座數 18 單位數目 11123 單位面積 151.23-397.73 呎（ft²） 住戶數目 10900 （截至2017年6月30日情況） 認可人口 28200 （截至2017年6月30日情況） 水泉澳邨內貌（2016年3月） 水泉澳邨 （ 英语： Shui Chuen O Estate ） [1] 是香港房屋委員會轄下的一個公共屋邨。全邨共分4期興建及管理，第1及2期樓宇由水泉澳邨辦事處管轄，第3及4期樓宇則由水泉澳邨辦事處分處管轄。項目編號為ST41，但已列入擴展市區配屋區內，位於香港新界沙田區水泉澳（沙田第52區）博泉街1號，已經興建18座樓高25至30層依山而建的住宅樓宇，共提供11,123個出租公屋單位，可容納人口逾29,000多人及水泉澳廣場，場內設有59個商舖及一個整體出租街市。水泉澳邨將設有行人天橋和升降機塔，接通博康邨和港鐵馬鞍山綫的沙田圍站；邨內亦設有公共交通交匯處及泊車位，方便居民出行。 整個項目於2015年4月至2017年3月分階段落成。整個項目由房屋署總建築師（1）負責總體設計；而詳細設計則拆細並以外判服務合約方式，第1及4期判給了周林建築師有限公司；第2A期（明泉樓、社會福利大樓、巴士總站、天橋及商場）及第3期（茂泉、林泉、修泉及竹泉樓）判給了興業建築師事務所有限公司及第2B期（月泉及映泉樓）判給了李景勳、雷煥庭建築師事務所；而第2C期（城泉及河泉樓）則由房屋署自行負責細部設計。全邨的總承建商是中國建築工程（香港）有限公司。 水泉澳邨共有18座出租公屋大樓，共分4期興建，第1期於2015年4月至7月底分2個階段完工，第2期在2016年3月至11月底分4個階段完工，第3期已於2017年2月完工交樓，第4期的嶺泉樓早已於2016年8月完工入伙，而餘下的崇泉、山泉及峻泉樓則由20
Read more

Indian Forest Service

Image
Indian Forest Service Service Overview Preceding service Imperial Forest Service (1864 to 1935) Year of Constitution 1966 Country India Staff College Indira Gandhi National Forest Academy (IGNFA), Dehradun, Uttarakhand Cadre Controlling Authority Ministry of Environment, Forests and Climate Change Legal personality Governmental: Government service General nature Administration of Forest and Wildlife resources Cadre strength 3131 (2182 Direct Recruits and 949 Promotion Posts) Website ifs.nic.in Service Chief Director General of Forests Siddhanth Das, IFS (1982 Batch, Odisha Cadre) [1] Head of the All India Civil Services Cabinet Secretary Pradeep Kumar Sinha, IAS Indian Forest Service (भारतीय वन सेवा) [2] is one of the three All India Services of the Government of India. The other two All India Services being the Indian Administrative Service (IAS) and the Indian Police Service (IPS). [3] [4] [5] It was constituted in
Read more