• integral component of membrane • plasma membrane • integral component of plasma membrane • extracellular exosome • membrane
Biological process
• sodium ion transport • Viral entry • phosphate ion transport • viral process • ion transport • sodium ion transmembrane transport • transmembrane transport • phosphate ion transmembrane transport • sodium-dependent phosphate transport • transport
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
6575
20516
Ensembl
ENSG00000168575
ENSMUSG00000037656
UniProt
Q08357
Q80UP8
RefSeq (mRNA)
NM_001257180 NM_001257181 NM_006749
NM_011394
RefSeq (protein)
NP_001244109 NP_001244110 NP_006740
NP_035524
Location (UCSC)
Chr 8: 42.42 – 42.54 Mb
Chr 8: 22.48 – 22.57 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sodium-dependent phosphate transporter 2 is a protein that in humans is encoded by the SLC20A2 gene.[5][6][7]
Contents
1Genomics
2Function
3Clinical significance
4See also
5References
6Further reading
Genomics
This gene is found on the short arm of chromosome 8 (8p12-p11) on the minus (Crick) strand. It is 123,077 bases in length. The encoded protein has 652 amino acids and the predicted molecular weight of the protein is 70.392 kiloDaltons.
Function
The protein acts as a homodimer and is involved in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis.
Clinical significance
Mutations in the SLC20a2 gene are associated with idiopathic basal ganglia calcification (Fahr's syndrome). This association suggests that familial idiopathic basal ganglia calcification is caused by changes in phosphate homeostasis, since this gene encodes for PIT-2, an inorganic phosphate transporter.[8]
See also
Solute carrier family
References
^ abcGRCh38: Ensembl release 89: ENSG00000168575 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000037656 - Ensembl, May 2017
^Kozak SL, Siess DC, Kavanaugh MP, Miller AD, Kabat D (Jun 1995). "The envelope glycoprotein of an amphotropic murine retrovirus binds specifically to the cellular receptor/phosphate transporter of susceptible species". J Virol. 69 (6): 3433–40. PMC 189055. PMID 7745689.
^Bottger P, Hede SE, Grunnet M, Hoyer B, Klaerke DA, Pedersen L (Nov 2006). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2". Am J Physiol Cell Physiol. 291 (6): C1377–87. doi:10.1152/ajpcell.00015.2006. PMID 16790504.
^"Entrez Gene: SLC20A2 solute carrier family 20 (phosphate transporter), member 2".
^Wang C, Li Y, Shi L, Ren J, Patti M, Wang T, de Oliveira JR, Sobrido MJ, Quintáns B, Baquero M, Cui X, Zhang XY, Wang L, Xu H, Wang J, Yao J, Dai X, Liu J, Zhang L, Ma H, Gao Y, Ma X, Feng S, Liu M, Wang QK, Forster IC, Zhang X, Liu JY (February 2012). "Mutations in SLC20A2 link familial idiopathic basal ganglia calcification with phosphate homeostasis". Nat Genet. 44 (3): 254–6. doi:10.1038/ng.1077. PMID 22327515.
Garcia JV, Jones C, Miller AD (1991). "Localization of the amphotropic murine leukemia virus receptor gene to the pericentromeric region of human chromosome 8". J. Virol. 65 (11): 6316–9. PMC 250343. PMID 1656098.
van Zeijl M, Johann SV, Closs E, et al. (1994). "A human amphotropic retrovirus receptor is a second member of the gibbon ape leukemia virus receptor family". Proc. Natl. Acad. Sci. U.S.A. 91 (3): 1168–72. doi:10.1073/pnas.91.3.1168. PMC 521475. PMID 8302848.
Salaün C, Gyan E, Rodrigues P, Heard JM (2002). "Pit2 assemblies at the cell surface are modulated by extracellular inorganic phosphate concentration". J. Virol. 76 (9): 4304–11. doi:10.1128/JVI.76.9.4304-4311.2002. PMC 155110. PMID 11932396.
Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function". J. Biol. Chem. 277 (45): 42741–7. doi:10.1074/jbc.M207096200. PMID 12205090.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bøttger P, Pedersen L (2004). "The central half of Pit2 is not required for its function as a retroviral receptor". J. Virol. 78 (17): 9564–7. doi:10.1128/JVI.78.17.9564-9567.2004. PMC 506934. PMID 15308749.
Bøttger P, Pedersen L (2005). "Evolutionary and experimental analyses of inorganic phosphate transporter PiT family reveals two related signature sequences harboring highly conserved aspartic acids critical for sodium-dependent phosphate transport function of human PiT2". FEBS J. 272 (12): 3060–74. doi:10.1111/j.1742-4658.2005.04720.x. PMID 15955065.
Ravera S, Virkki LV, Murer H, Forster IC (2007). "Deciphering PiT transport kinetics and substrate specificity using electrophysiology and flux measurements". Am. J. Physiol., Cell Physiol. 293 (2): C606–20. doi:10.1152/ajpcell.00064.2007. PMID 17494632.
This article is about the letter of the alphabet. For other uses, see Y (disambiguation). See also: Wye (disambiguation) Y Y y (See below) Usage Writing system Latin script Type Alphabetic and Logographic Language of origin Latin language Phonetic usage [ y ] [ ɨ ] [ j ] [ iː ] [ ɪ ] [ ɘ ] [ ə ] [ ɯ ] [ ɛː ] [ j ] [ ɥ ] [ ɣ̟ ] / w aɪ / / aɪ / Unicode value U+0059, U+0079 Alphabetical position 25 History Development Υ υ 𐌖 Y y Time period 54 to present Descendants • U • V • W • Ỿ • ¥ • Ꮙ • Ꮍ • Ꭹ Sisters F Ѵ У Ў Ұ Ү ו و ܘ וּ וֹ ࠅ 𐎆 𐡅 ወ વ ૂ ુ उ Variations (See below) Other Other letters commonly used with y(x), ly, ny This article contains IPA phonetic symbols. Without proper rendering support, you may see question marks, boxes, or other symbols instead of Unicode characters. For an introductory guide on IPA symbols, see Help:IPA. ISO basic Latin alphabet Aa Bb Cc D...
Mount Tamalpais Mount Tamalpais, viewed from the south Highest point Elevation 2,571 ft (784 m) NAVD 88 [1] Prominence 2,456 ft (749 m) [1] Listing California county high points 55th Coordinates 37°55′45″N 122°34′40″W / 37.929088°N 122.577829°W / 37.929088; -122.577829 Coordinates: 37°55′45″N 122°34′40″W / 37.929088°N 122.577829°W / 37.929088; -122.577829 [1] Geography Mount Tamalpais Marin County, California, U.S. Show map of California Mount Tamalpais Mount Tamalpais (the US) Show map of the US Parent range California Coast Ranges Topo map USGS San Rafael Geology Mountain type Sedimentary Climbing First ascent 1830s by Jacob P. Leese (first recorded ascent) [2] Easiest route Railroad Grade fire trail Mount Tamalpais ( / t æ m əl ˈ p aɪ . ɪ s / ; TAM -əl- PY -iss ; Coast Miwok: /t̪ɑmɑlˈpɑis̺/ , known locally as Mount Tam ) is a peak in Marin County, California, United State...
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