Fixed drug reaction










Fixed drug reaction
Specialty
Dermatology Edit this on Wikidata

Fixed drug reactions, also known as fixed drug eruptions, are common and so named because they recur at the same site with each exposure to a particular medication.[1] Medications inducing fixed drug eruptions are usually those taken intermittently.[1]




Contents






  • 1 Signs and symptoms


  • 2 Cause


  • 3 See also


  • 4 References


  • 5 External links





Signs and symptoms


A painful purple patch of skin that occurs in the same location with repeated exposures to the culprit drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.



Cause


Medications that are commonly implicated as a cause of fixed drug eruptions include the following:



  1. Fluconazole

  2. Ciprofloxacin

  3. Doxycycline

  4. Clarithromycin


  5. NSAIDs (e.g., ibuprofen)

  6. Trimethoprim

  7. Cotrimoxazole

  8. Phenytoin

  9. Cetirizine


  10. Pseudoephedrine[2]



See also



  • List of cutaneous conditions

  • List of human leukocyte antigen alleles associated with cutaneous conditions



References





  1. ^ ab James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. p. 127. ISBN 0-7216-2921-0..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"""""""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/6/65/Lock-green.svg/9px-Lock-green.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Lock-gray-alt-2.svg/9px-Lock-gray-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/thumb/a/aa/Lock-red-alt-2.svg/9px-Lock-red-alt-2.svg.png")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}


  2. ^ Vidal, Carmen; Pérez-Carral, Celsa; Armisén, Margarita; Prieto, Azucena (1998). "Nonpigmenting Fixed Drug Eruption due to Pseudoephedrine". Annals of Allergy, Asthma & Immunology. 80 (4): 309–10. doi:10.1016/S1081-1206(10)62974-2. PMID 9564979.




External links





Classification
D



  • ICD-10: L27.1 (ILDS L27.110)


  • ICD-9-CM: 692.3












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